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Knut R Steffensen Selected Research

Liver X Receptors

11/2021Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner.
1/2019Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease.
9/2016Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice.
2/2016Nuclear hormone receptor LXRα inhibits adipocyte differentiation of mesenchymal stem cells with Wnt/beta-catenin signaling.
1/2016The emerging roles of liver X receptors and their ligands in cancer.
7/2015Are Synthetic Compounds that Silence the Liver-X-Receptor the Next Generation of Anti-cancer Drugs?
5/2014Estrogen receptor ligands ameliorate fatty liver through a nonclassical estrogen receptor/Liver X receptor pathway in mice.
1/2014Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells.
1/2014LXR driven induction of HDL-cholesterol is independent of intestinal cholesterol absorption and ABCA1 protein expression.
8/2013The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils.
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Knut R Steffensen Research Topics

Disease

15Inflammation (Inflammations)
11/2021 - 12/2005
10Neoplasms (Cancer)
01/2019 - 01/2010
6Insulin Resistance
01/2022 - 08/2002
4Type 2 Diabetes Mellitus (MODY)
03/2016 - 08/2002
4Atherosclerosis
07/2014 - 08/2011
3Multiple Sclerosis
11/2021 - 12/2005
3Neuroinflammatory Diseases
11/2021 - 06/2010
3Obesity
03/2016 - 02/2010
3Neurodegenerative Diseases (Neurodegenerative Disease)
07/2012 - 10/2009
3Acute-Phase Reaction
08/2011 - 10/2004
3Cardiovascular Diseases (Cardiovascular Disease)
01/2007 - 04/2006
2Fatty Liver
01/2022 - 05/2014
2Infections
02/2016 - 06/2009
2Metabolic Diseases (Metabolic Disease)
01/2016 - 02/2010
2Disease Progression
06/2013 - 06/2010
2Breast Neoplasms (Breast Cancer)
06/2013 - 04/2009
2Parkinson Disease (Parkinson's Disease)
02/2013 - 10/2009
2Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
03/2006 - 08/2005
2Hepatocellular Carcinoma (Hepatoma)
12/2005 - 05/2002
1Non-alcoholic Fatty Liver Disease
01/2019
1Asthma (Bronchial Asthma)
09/2016
1Hyperplasia
09/2016
1Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left)
03/2016
1Body Weight (Weight, Body)
03/2016
1Type 1 Diabetes Mellitus (Autoimmune Diabetes)
03/2016
1Cardiomegaly (Heart Hypertrophy)
03/2016
1Cardiomyopathies (Cardiomyopathy)
03/2016
1Diabetic Cardiomyopathies
03/2016
1Cerebrotendinous Xanthomatosis
11/2014
1Paresis (Hemiparesis)
11/2014
1Inborn Genetic Diseases (Disease, Hereditary)
11/2014
1Muscle Spasticity (Spastic)
11/2014
1Communicable Diseases (Infectious Diseases)
07/2014
1Pathologic Processes
07/2014
1Adenocarcinoma
01/2014
1Retinoblastoma (Glioblastoma, Retinal)
11/2013
1Colorectal Neoplasms (Colorectal Cancer)
06/2013
1Demyelinating Diseases (Demyelinating Disease)
01/2012
1Peritonitis
08/2011
1Sepsis (Septicemia)
08/2011
1Amyloid Plaque
05/2011
1Alzheimer Disease (Alzheimer's Disease)
05/2011
1Gliosis
06/2010
1Endotoxemia
11/2009
1Tuberculosis (Tuberculoses)
06/2009
1Glucose Intolerance
11/2008

Drug/Important Bio-Agent (IBA)

21Liver X ReceptorsIBA
11/2021 - 12/2005
14CholesterolIBA
11/2021 - 04/2006
10Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA
01/2019 - 12/2005
10LigandsIBA
01/2019 - 08/2002
7LipidsIBA
01/2022 - 12/2005
6Glucose (Dextrose)FDA LinkGeneric
01/2022 - 01/2007
6Protein Isoforms (Isoforms)IBA
11/2021 - 05/2002
4GW 3965IBA
09/2016 - 11/2009
4CytokinesIBA
09/2016 - 08/2005
3Fatty Acids (Saturated Fatty Acids)IBA
01/2022 - 10/2004
3Insulin (Novolin)FDA Link
01/2022 - 03/2009
3EnzymesIBA
11/2014 - 12/2002
2OxysterolsIBA
07/2014 - 08/2013
2Estrogen ReceptorsIBA
05/2014 - 06/2013
2Hormones (Hormone)IBA
01/2014 - 06/2005
2Peptides (Polypeptides)IBA
05/2011 - 03/2006
2Pharmaceutical PreparationsIBA
01/2007 - 01/2007
2Myelin Basic ProteinIBA
03/2006 - 08/2005
1Cholesterol Esters (Cholesteryl Esters)IBA
01/2022
1Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA
01/2019
1RetinoidsIBA
01/2019
1Interleukin-13IBA
09/2016
1Proteins (Proteins, Gene)FDA Link
09/2016
1Interleukin-5 (Interleukin 5)IBA
09/2016
1OvalbuminIBA
09/2016
1Natriuretic PeptidesIBA
03/2016
1Triglycerides (Triacylglycerol)IBA
03/2016
1Streptozocin (Streptozotocin)FDA Link
03/2016
1methionylmethylsulfonium chloride (MMSC)IBA
02/2016
1Interleukin-1 (Interleukin 1)IBA
01/2016
1Interleukin-18 (Interleukin 18)IBA
01/2016
1cholestenoic acidIBA
11/2014
1Biological ProductsIBA
01/2014
1Ezetimibe (Zetia)FDA Link
01/2014
1HDL CholesterolIBA
01/2014
1Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
11/2013
1salicylhydroxamic acid (SHAM)IBA
08/2011
1Lipoproteins (Lipoprotein)IBA
08/2011
1Transcription Factors (Transcription Factor)IBA
08/2011
1Amyloid (Amyloid Fibrils)IBA
05/2011
1Co-Repressor ProteinsIBA
02/2010
1SulfotransferasesIBA
01/2010
1CC ChemokinesIBA
01/2010
1Dinoprostone (PGE2)FDA Link
11/2009
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2009
1Peptidoglycan (Murein)IBA
11/2009
1BilirubinIBA
11/2009
1Alanine Transaminase (SGPT)IBA
11/2009
1oxysterol binding proteinIBA
04/2009

Therapy/Procedure

5Therapeutics
01/2016 - 06/2009
1Liver Transplantation
01/2019
1Fat-Restricted Diet (Diet, Fat Restricted)
03/2016
1Ligation
08/2011
1Punctures
08/2011